Biochemical efficacy of vitamin D in ameliorating endocrine and metabolic disorders in diabetic rats.
作者： Kadry M. Sadek , Hazem Shaheen
DOI: 10.3109/13880209.2013.854812
关键词:
摘要: AbstractContext: Due to the biochemical role of vitamin D (Vit D) in endocrine system, especially its potential anti-inflammatory and immune-modulating properties, there is an increased interest prevention control diabetes mellitus.Objective: This study evaluated therapeutic efficacy Vit averting detrimental effects both types mellitus.Materials methods: A total 50 male Wistar rats were allotted into five groups: a placebo group; nongenetic model type 1 (T1D), injected with single dose streptozotocin (STZ; 65 mg/kg, ip); 2 (T2D), given short-term high-fat diet followed by low STZ (35 mg/kg, fourth fifth groups that gastrogavaged (10 IU/kg) three days after induction T1D T2D, respectively, which was continued daily throughout experiment.Results: (10 IU/kg/60 days) significantly (p < 0.0...
informahealthcare.com参考文章(47)
Giuseppe Paolisso, Maria Rosaria Rizzo, Gherardo Mazziotti, Maria Rosaria Tagliamonte, Antonio Gambardella, Mario Rotondi, Carlo Carella, Dario Giugliano, Michele Varricchio, Felice D’Onofrio, Advancing age and insulin resistance: role of plasma tumor necrosis factor-α American Journal of Physiology-endocrinology and Metabolism. ,vol. 275, ,(1998) , 10.1152/AJPENDO.1998.275.2.E294
Ken C Chiu, Audrey Chu, Vay Liang W Go, Mohammed F Saad, None, Hypovitaminosis D is associated with insulin resistance and β cell dysfunction The American Journal of Clinical Nutrition. ,vol. 79, pp. 820- 825 ,(2004) , 10.1093/AJCN/79.5.820
A. V. Taylor, P. H. Wise, Vitamin D replacement in Asians with diabetes may increase insulin resistance. Postgraduate Medical Journal. ,vol. 74, pp. 365- 366 ,(1998) , 10.1136/PGMJ.74.872.365
J.Fernando Bazan, Haemopoietic receptors and helical cytokines Immunology Today. ,vol. 11, pp. 350- 354 ,(1990) , 10.1016/0167-5699(90)90139-Z
P. Trinder, Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor Annals of Clinical Biochemistry. ,vol. 6, pp. 24- 27 ,(1969) , 10.1177/000456326900600108
Femke Baeke, Evelyne van Etten, Conny Gysemans, Lut Overbergh, Chantal Mathieu, Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities Molecular Aspects of Medicine. ,vol. 29, pp. 376- 387 ,(2008) , 10.1016/J.MAM.2008.05.004
N.J. Wareham, C.D. Byrne, C.N. Hales, D.I.W. Phillips, The 30 Minute Insulin Incremental Response in an Oral Glucose Tolerance Test as a Measure of Insulin Secretion Diabetic Medicine. ,vol. 12, pp. 931- 931 ,(1995) , 10.1111/J.1464-5491.1995.TB00399.X
C. Luo, J. Wong, M. Brown, M. Hooper, L. Molyneaux, D.K. Yue, Hypovitaminosis D in Chinese type 2 diabetes: Lack of impact on clinical metabolic status and biomarkers of cellular inflammation Diabetes and Vascular Disease Research. ,vol. 6, pp. 194- 199 ,(2009) , 10.1177/1479164109337974
Liviu G. Danescu, Shiri Levy, Joseph Levy, Vitamin D and diabetes mellitus. Endocrine. ,vol. 35, pp. 11- 17 ,(2009) , 10.1007/S12020-008-9115-5
X. Palomer, J. M. González-Clemente, F. Blanco-Vaca, D. Mauricio, Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes, Obesity and Metabolism. ,vol. 10, pp. 185- 197 ,(2008) , 10.1111/J.1463-1326.2007.00710.X