Tcr Modifications to Enhance Expression, Chain Pairing, and Antigen Recognition for Adoptive T Cell Transfer

摘要: T cell receptor (TCR) gene modified cells for adoptive transfer therapy have been shown to clinical success in treating melanoma and other malignancies by redirecting the specificity of peripheral blood lymphocytes (PBL) recognize tumor and/or viral associated antigens choice. One challenges using TCR is potential mispairing between endogenous and introduced alpha beta chains, allowing unwanted off-target reactivity, autoimmunity, or impaired therapeutic efficacy. approach augment proper chain pairing to enhance function involves modification introduced TCR genes promote pairing. Our studies demonstrated that while certain modifications a HCV NS3:1406-1415-reactive TCR can properly paired introduced TCRs expressed on the cell surface, this does not always correlate increased cell function. A better understanding how can influence will enhance our ability improve gene-modified adoptive transfer.