Loss of ARF Sensitizes Transgenic BRAFV600E Mice to UV-Induced Melanoma via Suppression of XPC
作者： Chi Luo , Jinghao Sheng , Miaofen G. Hu , Frank G. Haluska , Rutao Cui
DOI: 10.1158/0008-5472.CAN-12-4454
关键词:
摘要: Both genetic mutations and ultraviolet (UV) irradiation can predispose individuals to melanoma. Although BRAFV600E is the most prevalent oncogene in melanoma, mutant not sufficient induce tumors vivo. Mutation at CDKN2A locus another melanoma-predisposing event that disrupt function of both p16INK4a ARF. Numerous studies have focused on role but involvement ARF, a well-known p53 activator, still controversial. Using transgenic mouse model previously generated our laboratory, we report loss ARF able enhance spontaneous melanoma formation cause profound sensitivity neonatal UVB exposure. Mechanistically, deletion synergize inhibit nucleotide excision repair by epigenetically repressing XPC inhibiting E2F4/DP1 complex. We suggest promotes melanomagenesis abrogating activation acting concert with increase load DNA damage caused UV irradiation.
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Vijay Walia, Euphemia W. Mu, Jimmy C. Lin, Yardena Samuels, Delving into somatic variation in sporadic melanoma Pigment Cell & Melanoma Research. ,vol. 25, pp. 155- 170 ,(2012) , 10.1111/J.1755-148X.2012.00976.X
Zalfa A. Abdel-Malek, Ana Luisa Kadekaro, Viki B. Swope, Stepping up melanocytes to the challenge of UV exposure. Pigment Cell & Melanoma Research. ,vol. 23, pp. 171- 186 ,(2010) , 10.1111/J.1755-148X.2010.00679.X
Ruth Halaban, Wengeng Zhang, Antonella Bacchiocchi, Elaine Cheng, Fabio Parisi, Stephan Ariyan, Michael Krauthammer, James P McCusker, Yuval Kluger, Mario Sznol, None, PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells Pigment Cell & Melanoma Research. ,vol. 23, pp. 190- 200 ,(2010) , 10.1111/J.1755-148X.2010.00685.X
Blake Ferguson, H. Konrad Muller, Herlina Y. Handoko, Kiarash Khosrotehrani, Friedrich Beermann, Elke Hacker, H. Peter Soyer, Marcus Bosenberg, Graeme J. Walker, Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis. Pigment Cell & Melanoma Research. ,vol. 23, pp. 771- 780 ,(2010) , 10.1111/J.1755-148X.2010.00752.X
Samir Kumar Patra, Ras regulation of DNA-methylation and cancer. Experimental Cell Research. ,vol. 314, pp. 1193- 1201 ,(2008) , 10.1016/J.YEXCR.2008.01.012
Y-H Wu, J-H Tsai Chang, Y-W Cheng, T-C Wu, C-Y Chen, H Lee, Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers Oncogene. ,vol. 26, pp. 4761- 4773 ,(2007) , 10.1038/SJ.ONC.1210284
E.Elizabeth Patton, Hans R. Widlund, Jeffery L. Kutok, Kamden R. Kopani, James F. Amatruda, Ryan D. Murphey, Stephane Berghmans, Elizabeth A. Mayhall, David Traver, Christopher D.M. Fletcher, Jon C. Aster, Scott R. Granter, A.Thomas Look, Charles Lee, David E. Fisher, Leonard I. Zon, BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma Current Biology. ,vol. 15, pp. 249- 254 ,(2005) , 10.1016/J.CUB.2005.01.031
Frances P. Noonan, James Dudek, Glenn Merlino, Edward C. De Fabo, Animal models of melanoma: an HGF/SF transgenic mouse model may facilitate experimental access to UV initiating events. Pigment Cell Research. ,vol. 16, pp. 16- 25 ,(2003) , 10.1034/J.1600-0749.2003.00014.X
Hans R. Widlund, David E. Fisher, Potent p53‐independent tumor suppressor activity of ARF in melanoma‐genesis Pigment Cell Research. ,vol. 20, pp. 339- 340 ,(2007) , 10.1111/J.1600-0749.2007.00401.X
Takehiko Kamijo, Frederique Zindy, Martine F. Roussel, Dawn E. Quelle, James R. Downing, Richard A. Ashmun, Gerard Grosveld, Charles J. Sherr, Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF Cell. ,vol. 91, pp. 649- 659 ,(1997) , 10.1016/S0092-8674(00)80452-3