Severe leukopenia in Staphylococcus aureus-necrotizing, community-acquired pneumonia: risk factors and impact on survival

作者: Nagham Khanafer , Nicolas Sicot , Philippe Vanhems , Oana Dumitrescu , Vanina Meyssonier

DOI: 10.1186/1471-2334-13-359

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摘要: Background Necrotizing pneumonia attributed to Panton-Valentine leukocidin-positive Staphylococcus aureus has mainly been reported in otherwise healthy children and young adults, with a high mortality rate. Erythroderma, airway bleeding, leukopenia have shown be predictive of mortality. The objectives this study were define the characteristics patients severe at 48-h hospitalization update our data regarding predicting factors larger population than we had previously described.

参考文章(27)
Klaudia Kuranda, Jacques Vargaftig, Philippe de la Rochere, Christine Dosquet, Dominique Charron, Florence Bardin, Cecile Tonnelle, Dominique Bonnet, Michele Goodhardt, Age-related changes in human hematopoietic stem/progenitor cells. Aging Cell. ,vol. 10, pp. 542- 546 ,(2011) , 10.1111/J.1474-9726.2011.00675.X
O. Dumitrescu, C. Badiou, M. Bes, M.-E. Reverdy, F. Vandenesch, J. Etienne, G. Lina, Effect of antibiotics, alone and in combination, on Panton–Valentine leukocidin production by a Staphylococcus aureus reference strain Clinical Microbiology and Infection. ,vol. 14, pp. 384- 388 ,(2008) , 10.1111/J.1469-0691.2007.01947.X
Véronique Boussaud, Antoine Parrot, Charles Mayaud, Marie Wislez, Martine Antoine, Clément Picard, Françoise Delisle, Jérome Etienne, Jacques Cadranel, Life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus. Intensive Care Medicine. ,vol. 29, pp. 1840- 1843 ,(2003) , 10.1007/S00134-003-1918-5
Anne-Laure Genestier, Marie-Cécile Michallet, Gilles Prévost, Gregory Bellot, Lara Chalabreysse, Simone Peyrol, Françoise Thivolet, Jerome Etienne, Gérard Lina, François M. Vallette, François Vandenesch, Laurent Genestier, Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils Journal of Clinical Investigation. ,vol. 115, pp. 3117- 3127 ,(2005) , 10.1172/JCI22684
Melissa T. Bartman, Zhanna Kaidarova, Dale Hirschkorn, Ronald A. Sacher, Joy Fridey, George Garratty, Joan Gibble, James W. Smith, Bruce Newman, Anthony E. Yeo, Edward L. Murphy, Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection Blood. ,vol. 112, pp. 3995- 4002 ,(2008) , 10.1182/BLOOD-2008-05-155960
Jean-Philippe Rasigade, Nicolas Sicot, Frederic Laurent, Gerard Lina, François Vandenesch, Jerome Etienne, A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associated pneumonia. Vaccine. ,vol. 29, pp. 4185- 4186 ,(2011) , 10.1016/J.VACCINE.2011.04.033
Y. Gillet, P. Vanhems, G. Lina, M. Bes, F. Vandenesch, D. Floret, J. Etienne, Factors Predicting Mortality in Necrotizing Community-Acquired Pneumonia Caused by Staphylococcus aureus Containing Panton-Valentine Leukocidin Clinical Infectious Diseases. ,vol. 45, pp. 315- 321 ,(2007) , 10.1086/519263
Sophie de Bentzmann, Anne Tristan, Jerome Etienne, Nicole Brousse, François Vandenesch, Gerard Lina, Staphylococcus aureus isolates associated with necrotizing pneumonia bind to basement membrane type I and IV collagens and laminin. The Journal of Infectious Diseases. ,vol. 190, pp. 1506- 1515 ,(2004) , 10.1086/424521
B. E. Gonzalez, K. G. Hulten, M. K. Dishop, L. B. Lamberth, W. A. Hammerman, E. O. Mason, S. L. Kaplan, Pulmonary Manifestations in Children with Invasive Community-Acquired Staphylococcus aureus Infection Clinical Infectious Diseases. ,vol. 41, pp. 583- 590 ,(2005) , 10.1086/432475