Neurotensin is Metabolized by Endogenous Proteases in Prostate Cancer Cell Lines
作者： Terry W Moody , Craig A Mayr , Terry J Gillespie , Thomas P Davis
DOI: 10.1016/S0196-9781(97)00306-9
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摘要: Moody, T. W., C. A. Mayr, J. Gillespie and P. Davis. Neurotensin is metabolized by endogenous proteases in prostate cancer cell lines. Peptides 19(2) 253–258, 1998.—The formation processing of neurotensin (NT) three lines was investigated. immunoreactivity detected conditioned media extracts LNCaP cells. Using HPLC techniques, the extracted from cells coeluted with synthetic NT standard. Metalloendopeptidase 3.4.24.15 activity PC-3, DU-145 cells, whereas high levels neutral endopeptidase 3.4.24.11 only relatively stable when incubated PC-3 or D-145 but rapidly degraded to NT1–11 NT1–10. Phosphoramidon inhibited metabolism These data suggest that present cellular enzymes.
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