Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function.
作者： T Inaba , H Shimano , T Gotoda , K Harada , M Shimada
DOI: 10.1016/S0021-9258(20)80533-X
关键词:
摘要: Platelet-derived growth factor (PDGF) plays an important role in the process of atherosclerosis which is characterized by presence macrophage-derived foam cells. In present study, induction mRNA PDGF-beta receptor was demonstrated during cell differentiation human monocyte-macrophages, whereas no detected cells early days culture. Flow cytometry analysis using antibodies specific for and CD14 showed both on monocyte-derived macrophages, monocytes 4 h after adhesion to a culture dish. binding assay PDGF-BB saturable high affinity site with Kd 27.5 pM Bmax 23.3 fmol/mg protein demonstrated. When were cultured kinase C inhibitor staurosporine, inhibited, tetradecanoylphorbol acetate enhanced expression indicating that associated maturation monocyte-macrophages through activation C. response homodimer, phosphorylated, thymidine uptake inositol trisphosphate production stimulated macrophages. Furthermore, suppressed macrophages colony-stimulating The suggests PDGF influences regulating function as well smooth muscle vascular wall.
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