Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivative for bacterial skin infection

摘要: Folliculitis, furunculosis and acne vulgaris are very common skin disorders of the hair follicles associated with large grease-producing (sebaceous) glands. Although detailed mechanisms involved these not fully understood, it is believed that bacteria Propionibacterium acnes Staphylococcus aureus key pathogenic factors involved. Conventional treatments targeting include a variety topical oral medications such as antibiotics. The wide use antibiotics leads to bacterial resistance, hence there need for new alternatives in above treatment. Photodynamic antimicrobial chemotherapy (PACT) based on an initial photosensitization infected area, followed by irradiation visible light, producing singlet oxygen which cytotoxic bacteria. Herein we reported zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine (ZnPc-(Lys) 5 ) its PACT effect infections. Our results demonstrated strong bactericidal effects this photosensitizer both strains bacteria, suggesting ZnPc-(Lys) promising treatment infectious diseases caused