An effective zinc phthalocyanine derivative for photodynamic antimicrobial chemotherapy

摘要: Bacterial infection is a common clinical problem. The emergence of antibiotic resistant bacteria posts severe challenge to medical practice worldwide. Photodynamic antimicrobial chemotherapy (PACT) uses laser light at specific wavelength activate oxygen molecule in the human tissue into reactive species as agent. This activation by mediated through photosensitizer. Two key properties for potent photosensitizer are its absorbance infrared region (630–700 nm), which promotes penetration depth, and selective accumulation on instead tissue. We herein report zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine (ZnPc-(Lys)5) effects vitro an animal model. has strong capability kill 670 nm. Chemically, it water-soluble cationic carrying positive charge under physiological pH, can specifically target usually bears negative charges surface. Compared with anionic ZnPc counterparts, ZnPc-(Lys)5 shows higher phototoxicity toward bacteria. PACT studies experimental model showed significant inhibition compared controls, high selectivity These findings suggest promising treatment infectious diseases.