Antimicrobial Photodynamic Therapy (APDT) Action Based on Nanostructured Photosensitizers

摘要: Important features are linked to the concept of antimicrobial photodynamic therapy (APDT). One approach is need effective strategies overcome bacterial resistance antibiotics. In this context, APDT has emerged as a valuable method, once cellular death mediated by production reactive oxygen or nitrogen species (ROS RNS), so it very unlikely that resistant microorganisms may be selected. Another regards photobiomodulation on wound healing for, simultaneously, antibacterial and remodeling tissue effects, severe wounds normally compromised infection. with appropriate photoactive nanodrugs specially designed for purpose contribute both regenerative process skin at same time protects eradicates infections, accelerating less no side effects. Several issues involved APDT, among design choice nanostructured photosensitizer how certificate will penetrate cytoplasm specific organelles in target tissue. For instance, Gram-positive bacteria sensitive wide range porphyrins phthalocyanine compounds used nanoencapsulated photosensitizers. On other hand, Gram-negative have considerable process, their external membrane act barrier permeability drug, besides being negatively charged. New efforts under study good results eradication microorganisms, such bacteria, fungi, viruses, protozoa, photoinactivation. Therefore, selection an ideal nanomaterial drug delivery system crucial understand develop more efficient protocols based mechanisms inactivation.