Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus.
作者： Oliver von Bohlen und Halbach
DOI: 10.1007/S00441-011-1196-4
关键词:
摘要: Biologists long believed that, once development is completed, no new neurons are produced in the forebrain. However, as now firmly established, can be at least two specific forebrain areas: subventricular zone (SVZ) and dentate gyrus (DG) of hippocampal formation. Neurogenesis within adult DG occurs constitutively throughout postnatal life, rate neurogenesis altered under various physiological pathophysiological conditions. The process a multi-step (proliferation, differentiation, migration, targeting, synaptic integration) that ends with formation post-mitotic functionally integrated neuron. Various markers expressed during stages neurogenesis. availability such allows time-course fate newly born cells to followed detailed precise fashion. Several available (e.g., PCNA, Ki-67, PH3, MCM2) for proliferative events, whereas others more early phases gliogenesis nestin, GFAP, Sox2, Pax6). In addition, allowing events distinguished related later steps vimentin, BLBP, S100beta) or NeuroD, PSA-NCAM, DCX).
springer.com
sci-hub.se 参考文章(223)
Patrizia Ambrogini, Davide Lattanzi, Stefano Ciuffoli, Deborah Agostini, Luana Bertini, Vilberto Stocchi, Spartaco Santi, Riccardo Cuppini, Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus. Brain Research. ,vol. 1017, pp. 21- 31 ,(2004) , 10.1016/J.BRAINRES.2004.05.039
Tobi L. Limke, Jingli Cai, Takumi Miura, Mahendra S. Rao, Mark P. Mattson, Distinguishing features of progenitor cells in the late embryonic and adult hippocampus. Developmental Neuroscience. ,vol. 25, pp. 257- 272 ,(2003) , 10.1159/000072273
Kharen L. Doyle, Monaliza Khan, Anne M. Cunningham, Expression of the intermediate filament protein nestin by sustentacular cells in mature olfactory neuroepithelium The Journal of Comparative Neurology. ,vol. 437, pp. 186- 195 ,(2001) , 10.1002/CNE.1278
P. J. Bernier, A. Bedard, J. Vinet, M. Levesque, A. Parent, Newly generated neurons in the amygdala and adjoining cortex of adult primates Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 11464- 11469 ,(2002) , 10.1073/PNAS.172403999
H. van Praag, B. R. Christie, T. J. Sejnowski, F. H. Gage, Running enhances neurogenesis, learning, and long-term potentiation in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 13427- 13431 ,(1999) , 10.1073/PNAS.96.23.13427
A. Y. Maslov, Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice The Journal of Neuroscience. ,vol. 24, pp. 1726- 1733 ,(2004) , 10.1523/JNEUROSCI.4608-03.2004
H. Cremer, G. Chazal, P.M. Lledo, G. Rougon, M.F. Montaron, W. Mayo, M. Le Moal, D.N. Abrous, PSA-NCAM: an important regulator of hippocampal plasticity. International Journal of Developmental Neuroscience. ,vol. 18, pp. 213- 220 ,(2000) , 10.1016/S0736-5748(99)00090-8
Oliver von Bohlen und Halbach, Involvement of BDNF in age-dependent alterations in the hippocampus. Frontiers in Aging Neuroscience. ,vol. 2, ,(2010) , 10.3389/FNAGI.2010.00036
Tracey J. Shors, David A. Townsend, Mingrui Zhao, Yevgenia Kozorovitskiy, Elizabeth Gould, Neurogenesis may relate to some but not all types of hippocampal-dependent learning Hippocampus. ,vol. 12, pp. 578- 584 ,(2002) , 10.1002/HIPO.10103
Sebastian Jessberger, Benedikt Römer, Harish Babu, Gerd Kempermann, Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells. Experimental Neurology. ,vol. 196, pp. 342- 351 ,(2005) , 10.1016/J.EXPNEUROL.2005.08.010