Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole.

摘要: Twenty-one women were studied who had received propylthiouracil or methimazole during 26 pregnancies. Four of the infants a goiter at birth, and 3 these neonatal thyrotoxicosis. In 2 children thyrotoxicosis was not evident birth because maternal antithyroid therapy. Five congenital defects. Two mothers responsible for 4 with abnormalities, both been treated thiourea drugs long periods, ranging from 7 to 11 years. The majority are exposed in utero appear have no subsequent ill effects. However, prolonged therapy agents may be undesirable.