Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration.

作者: Nashwa El-Gendy , Cory Berkland

DOI: 10.1007/S11095-009-9886-2

关键词:

摘要: Purpose To develop an aerosol system for efficient local lung delivery of chemotherapeutics where nanotechnology holds tremendous potential developing more valuable cancer therapies. Concurrently, aerosolized chemotherapy is generating interest as a means to treat certain types effectively with less systemic exposure the compound.

参考文章(63)
Robert Perkel, Christopher Haines, Lauren G. Collins, Robert E. Enck, Lung Cancer: Diagnosis and Management American Family Physician. ,vol. 75, pp. 56- 63 ,(2007)
Konstantinos A Ekmektzoglou, Theodoros Xanthos, Georgios C Zografos, Georgios F Samelis, Small-cell lung cancer: an unusual therapeutic approach with more than 10-year overall survival. Case report and review of the literature. Tumori. ,vol. 94, pp. 612- 616 ,(2008) , 10.1700/371.4350
Yuichi Sugiyama, Nobuhiro Nishiyama, Souichiro Okazaki, Horacio Cabral, Yasuhiro Matsumura, Masaki Miyamoto, Kazuto Nishio, Kazunori Kataoka, Yukio Kato, Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice Cancer Research. ,vol. 63, pp. 8977- 8983 ,(2003)
N. R. Labiris, M. B. Dolovich, Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications British Journal of Clinical Pharmacology. ,vol. 56, pp. 588- 599 ,(2003) , 10.1046/J.1365-2125.2003.01892.X
Michael E. Aulton, Pharmaceutics : the science of dosage form design Churchill Livingstone. ,(2002)
Rita Vanbever, Jeffrey D. Mintzes, Jue Wang, Jacquelyn Nice, Donghao Chen, Richard Batycky, Robert Langer, David A. Edwards, Formulation and physical characterization of large porous particles for inhalation. Pharmaceutical Research. ,vol. 16, pp. 1735- 1742 ,(1999) , 10.1023/A:1018910200420
Martin J Telko, Anthony J Hickey, Dry powder inhaler formulation. Respiratory Care. ,vol. 50, pp. 1209- 1227 ,(2005)
Rita Vanbever, Abdellaziz Ben-Jebria, Jeffrey D. Mintzes, Robert Langer, David A. Edwards, Sustained release of insulin from insoluble inhaled particles Drug Development Research. ,vol. 48, pp. 178- 185 ,(1999) , 10.1002/(SICI)1098-2299(199912)48:4<178::AID-DDR5>3.0.CO;2-I
Yu Liu, Guo-Song Chen, Yong Chen, Dong-Xu Cao, Zhi-Qiang Ge, Ying-Jin Yuan, Inclusion complexes of paclitaxel and oligo(ethylenediamino) bridged bis(β-cyclodextrin)s: solubilization and antitumor activity Bioorganic & Medicinal Chemistry. ,vol. 12, pp. 5767- 5775 ,(2004) , 10.1016/J.BMC.2004.08.040
P. Vijayaraj Kumar, Narendr K. Jain, Suppression of agglomeration of ciprofloxacin-loaded human serum albumin nanoparticles. Aaps Pharmscitech. ,vol. 8, pp. 17- 17 ,(2007) , 10.1208/PT0801017