Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
作者： Pengfei Cheng , Lingjian Zhu , Wei Guo , Wenfeng Liu , Jianzhong Yao
DOI: 10.3109/14756366.2011.595712
关键词:
摘要: Structure modification of the side chain lead compound benzoxanthone provided a series analogues and 12 them were first reported. The results showed that most these compounds had moderate cytotoxicity against tumour cells with 50% inhibition concentration in micromolar range. Furthermore, derivatives 5, 6c, 7a 7e, potent topoisomerase I (Topo I) inhibitory effect indicated some potential for development as non-Camptothecin (CPT) inhibitors.
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