Synthesis and antithrombotic effect of xanthone derivatives.
作者： Chun-Nan Lin , Hsin-Kaw Hsieh , Shiou-Jyh Liou , Horng-Huey Ko , Hsien-Cheng Lin
DOI: 10.1111/J.2042-7158.1996.TB05994.X
关键词:
摘要: A series of xanthone derivatives was synthesized and tested in-vitro for their ability to inhibit aggregation rabbit washed platelets human platelet-rich plasma (PRP) induced by various inducers. 2-Prenyloxyxanthone showed the most potent inhibition platelet arachidonic acid (IC50 = 10.2 μM). Of compounds in PRP, 2-[3 (propylamino)-2-hydroxypropoxy]xanthone (4) hydrochloride salt exhibited adrenaline 4.4 μM), whereas evaluation mouse antithrombotic activity, compound 4 protection mice from thrombotic challenge. Compound 4, 2-[3-(isopropylamino)-2-hydroxypropoxylxanthone 2,5 dihydroxyxanthone suppressed secondary PRP. We conclude that antiplatelet effects these are mainly due an inhibitory effect on thromboxane formation.
sci-hub.se 参考文章(6)
M J Silver, G DiMinno, Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol. Journal of Pharmacology and Experimental Therapeutics. ,vol. 225, pp. 57- 60 ,(1983)
Chun-Nan Lin, Shorong-Shii Liou, Shih-Chen Lai, Hsien-Cheng Lin, Feng-Nien Ko, Hong-Wen Liu, Che-Ming Teng, Synthesis and antiplatelet effects of ω-aminoalkoxylxanthones Journal of Pharmacy and Pharmacology. ,vol. 47, pp. 588- 594 ,(2011) , 10.1111/J.2042-7158.1995.TB06720.X
Chun-Nan Lin, Shorong-Shii Liou, Feng-Nien Ko, Che-Ming Teng, γ-pyrone compounds. IV: Synthesis and antiplatelet effects of mono- and dioxygenated xanthones and xanthonoxypropanolamine Journal of Pharmaceutical Sciences. ,vol. 82, pp. 11- 16 ,(1993) , 10.1002/JPS.2600820103
Ing-Jun Chen, Shwu-Jen Liou, Shorong-Shii Liou, Chun-Nan Lin, Xanthonolol: A calcium channel and beta-adrenoceptor blocker with vasodilating properties General Pharmacology: The Vascular System. ,vol. 24, pp. 1425- 1433 ,(1993) , 10.1016/0306-3623(93)90430-6
CHUN-NAN LIN, MEI-ING CHUNG, SHIOU-JYH LIOU, TAI-HUA LEE, JIP-PYANG WANG, Synthesis and anti-inflammatory effects of xanthone derivatives. Journal of Pharmacy and Pharmacology. ,vol. 48, pp. 532- 538 ,(2011) , 10.1111/J.2042-7158.1996.TB05969.X
Chun-Nan Lin, Hsin-Kaw Hsieh, Shiou-Jyh Liou, Horng-Huey Ko, Hsien-Cheng Lin, Mei-Ing Chung, Feng-Nien Ko, Hong-Wen Liu, Che-Ming Teng, Synthesis and antithrombotic effect of xanthone derivatives. Journal of Pharmacy and Pharmacology. ,vol. 48, pp. 887- 890 ,(2011) , 10.1111/J.2042-7158.1996.TB05994.X