Prevalence, risk factors, and impact on outcome of cytomegalovirus replication in serum of Cambodian HIV-infected patients (2004-2007).

摘要: Background: In developing countries, the study of cytomegalovirus (CMV) coinfection in HIV-infected patients remains neglected. Quantitative CMV polymerase chain reaction (PCR) is gold standard diagnostic tool for analyzing serum replication and predicting disease. We estimated prevalence replicating sera newly diagnosed Cambodian examined its impact on mortality. Methods: This cohort was based 2 highly active antiretroviral therapy treatment programs Cambodia between 2004 2007. PCR performed baseline samples 377 patients. Results: The DNA 55.2% (150 272) with CD4 + count <100/mm 3 . multivariate analysis, hemoglobin <9 g/dL, CD4' , Karnofsky index <50 were independently associated positive at baseline. During a 3-year follow-up period, viral load ≥3.1 log 10 copies per milliliter significantly death count, other opportunistic infections, therapy. Conclusions: As industrialized prevalent among increased underscores importance infection by < 100/mm treating this to reduce