Late Onset of Bladder Urothelial Carcinoma After Kidney Transplantation for End-Stage Aristolochic Acid Nephropathy: A Case Series With 15-Year Follow-up

摘要: Background Aristolochic acids are nephrotoxins and predispose to upper-tract urothelial carcinoma. The risk of bladder carcinoma after kidney transplantation its relationship is not well defined. Study Design Case series. Setting & Participants Single-center cohort 38 women given transplants for end-stage aristolochic acid nephropathy. Outcomes Measurements prevalence upper urinary tract was determined by collecting pathological results specimens obtained means bilateral ureteronephrectomy. We also established the cumulative incidence in biopsies performed during prospective screening cystoscopies a 15-year follow-up. Results Upper-tract found 17 patients with nephropathy (44.7%). During follow-up, diagnosed 15 68 169 months cessation exposure (39.5%): 8 situ, 4 noninvasive low-grade papillary carcinoma, 3 infiltrating 12 (71%) history developed whereas this occurred only 21 (14%) without ( P Limitations Small sample size case Conclusions dramatic complications transplant recipients nephropathy, confirming carcinogenic properties acids. identified as potent factor subsequent development Because complication may occur years discontinuation, we suggest regular addition ureteronephrectomy