Species Differences in Oxidative Drug Metabolism: Some Basic Considerations

摘要: Perhaps one of the single most important developments in past 20 years understanding chemical toxicity has been realisation importance metabolic transformation this process. It is now widely appreciated that toxic effects many chemicals a function their metabolism rather than substance itself. Of central interest to toxicologist therefore an and significance The process itself however can be highly variable both between within animal species. For reason may have consider species strain differences when attempting extrapolate findings man safety evaluation twenty years, work on largely descriptive nature cataloguing differences. However, last few genetic diversity species, including man, terms biotransformation substrate preferences various multiple forms drug-metabolizing enzymes give better insight into metabolism. Furthermore, problem tempers expectations what hoped for extrapolation from other example, search metabolizes like will seen ill-conceived ill-advised. presentation deals with some fundamental aspects oxidative particular implications