Toxicological Implications of Polymorphic Drug Metabolism

摘要: The occurrence of genetic polymorphisms drug metabolism means that populations contain subgroups (phenotypes) differ sharply in their abilities to effect a number metabolic reactions. Because this, major interphenotype differences occur responsiveness drugs and toxic substances. well established acetylation hydrolysis illustrate the important association exists between phenotype propensity develop exaggerated responses some Recently, for oxidation, new polymorphism has been described it promises provide better understanding inter-individual variability handling of, to, following effects are here: (a) its influence determining variable presystemic hence systemic availability; (b) role alternative pathways individuals who have genetically determined impairment oxidative capacity (c) on development agranulocytosis associated with metiamide administration.