The blood transfusion effect: clinical aspects.

摘要: Abstract In 1973, Opelz et al. demonstrated a one-year renal transplant survival of 29% in patients who had never been transfused and 66% those receiving over ten units blood before transplantation [4]. Subsequent reports were contradictory, but by the early 1980s it was generally accepted that pretransplant transfusions beneficial. By 1983 only 4% awaiting untransfused. Since 1985 data have again become much less clear. 1987, [28] showed no improvement survival, irrespective whether immunosuppression with cyclosporin or conventional therapy. Recently, however, several American studies shown beneficial effects particularly well matched for HLA antigens their donor. There is evidence also transfusion from specific donor improves living related The risk sensitisation can be minimised giving along transfusion. Mechanism effect unclear, following suggested: (a) clonal deletion inactivation; (b) induction suppressor lymphocytes; (c) presence blocking alloantibodies anti-idiotypic antibodies. clearly need to determine large still exists, whether, example, numbers rejection episodes which require expensive therapy are different non-transfused patients. As erythropoetin now used prevent anaemia dialysis patients, may infrequently necessary. Some centres show graft around 80% at one year received transfusion, this attributed more successful immunosuppressive addition, themselves not without risk, virus transmission. A policy deliberate 1990s must remain under constant review.