Ocular Surface Squamous Neoplasia in 200 Patients: A Case-Control Study of Immunosuppression Resulting from Human Immunodeficiency Virus versus Immunocompetency

摘要: Purpose To describe and compare the clinical presentation, treatment outcomes, histopathologic features of ocular surface squamous neoplasia (OSSN) based on human immunodeficiency virus (HIV) status. Design Case-control study. Participants A total 200 patients with OSSN, whom 83 (41%) had positive results for HIV were classified as cases 117 (59%) negative controls. Methods Enzyme-linked immunosorbent assay HIV, conjuntival excision biopsy, extended enucleation, orbital exenteration. Main Outcome Measures Clinical features, characteristics. Results The mean age at presentation OSSN in both controls was 40 years (median, years; range, 13–65 years) 38 15–80 years). On comparison versus HIV-positive individuals larger (12 vs. 8 mm; P  = 0.041) tumors, a higher incidence corneal (60% 40%;  = 0.007), scleral (19% 9%; 0.044), (13% 3%; 0.019) invasion need enucleation or exenteration (27% 11%; 0.13), lamellar sclerectomy 8%; 0.29), tumor recurrence after primary (30% 20%; 0.12) compared HIV-negative However, these not statistically significant. Based American Joint Committee Cancer classification, T1 more common 35% controls; 0.0009), T4 4%  = 0.019). None demonstrated systemic metastases died disease during follow-up period 10 months 4 months; Conclusions Ocular is aggressive and thicker tumors corneal, scleral, invasion. These are associated poor prognosis exenteration, both.