Comparison of visual and ROI-based brain tumour grading using 18F-FDG PET: ROC analyses.

摘要: Several studies have suggested that the use of simple visual interpretation criteria for investigation brain tumours by positron emission tomography with fluorine-18 fluorodeoxyglucose (FDG-PET) might be similarly or even more accurate than quantitative semi-quantitative approaches. We investigated this hypothesis comparing accuracy FDG-PET tumour grading using a proposed six-step scale (VGS; applied three independent observers unaware clinical history and results histopathology) different region interest (ROI) ratios (maximal uptake compared contralateral tissue [Tu/Tis], grey matter [Tu/GM] white [Tu/WM]). The patient population comprised 47 patients suffering from 17 benign (7 gliomas grade II, 10 non-gliomatous tumours) 30 malignant (23 III–IV, 7 tumours. VGS were highly correlated ROI (R=0.91 Tu/GM, R=0.82 Tu/WM, R=0.79 Tu/Tis), high inter-observer agreement was achieved (κ=0.63, 0.76 0.81 observers). mean readings gliomatous lesions not significantly different. For all measures, high-grade showed higher FDG low-grade (P > WM). yielded highest Az (±SE) value (i.e. area under ROC curve as measure predicted accuracy), 0.97±0.03, which strong tendency towards being greater Tu/Tis (0.88±0.06; P=0.06). Tu/GM (0.92±0.04) Tu/WM (0.91±0.05) reached intermediate values (not any other value). conclude represents at least ratios. ratio is less valid owing to dependence on location lesion. Depending investigator's experience structure lesions, easily used most favourable criterion.