Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging

作者: Joyce C. McCann , Bruce N. Ames

DOI: 10.1096/FJ.11-180885

关键词:

摘要: The triage theory proposes that modest deficiency of any vitamin or mineral (V/M) could increase age-related diseases. V/M-dependent proteins required for short-term survival and/or reproduction (i.e., "essential") are predicted to be protected on V/M over other "nonessential" needed only long-term health. result is accumulation insidious damage, increasing disease risk. We successfully tested the against published evidence K. Here, we review about half 25 known mammalian selenoproteins; all those with mouse knockout human mutant phenotypes used as criteria a classification essential nonessential. Five selenoproteins (Gpx4, Txnrd1, Txnrd2, Dio3, and Sepp1) were classified 7 (Gpx1, Gpx 2, 3, Dio1, Dio2, Msrb1, SelN) On selenium (Se) deficiency, nonessential selenoprotein activities concentrations preferentially lost, one exception (Dio1 in thyroid, which predict conditionally essential). Mechanisms include requirement special form tRNA sensitive Se translation mRNAs except Dio1. same set diseases conditions, including cancer, heart disease, immune dysfunction, prospectively associated also genetic dysfunction selenoproteins, suggesting causal factor, possibility strengthened by mechanistic evidence. Modest common many parts world; optimal intake prevent future disease.

参考文章(296)
Fong-Fong Chu, H.A. Rohan de Silva, R.Steven Esworthy, Kalina K. Boteva, Claire E. Walters, Allen Roses, P.Nagesh Rao, Mark J. Pettenati, Polymorphism and chromosomal localization of the GI-form of human glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization. Genomics. ,vol. 32, pp. 272- 276 ,(1996) , 10.1006/GENO.1996.0115
A. Chidakel, D. Mentuccia, F.S. Celi, Peripheral metabolism of thyroid hormone and glucose homeostasis. Thyroid. ,vol. 15, pp. 899- 903 ,(2005) , 10.1089/THY.2005.15.899
Laura V. Papp, Arne Holmgren, Kum Kum Khanna, Selenium and selenoproteins in health and disease. Antioxidants & Redox Signaling. ,vol. 12, pp. 793- 795 ,(2010) , 10.1089/ARS.2009.2973
Holger Steinbrenner, Bodo Speckmann, Antonio Pinto, Helmut Sies, High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism Journal of Clinical Biochemistry and Nutrition. ,vol. 48, pp. 40- 45 ,(2010) , 10.3164/JCBN.11-002FR
Fulvio Ursini, Sabina Heim, Michael Kiess, Matilde Maiorino, Antonella Roveri, Josef Wissing, Leopold Flohé, Dual Function of the Selenoprotein PHGPx During Sperm Maturation Science. ,vol. 285, pp. 1393- 1396 ,(1999) , 10.1126/SCIENCE.285.5432.1393
Robertas Bunevičius, Arthur J Prange, Thyroid disease and mental disorders: cause and effect or only comorbidity? Current Opinion in Psychiatry. ,vol. 23, pp. 363- 368 ,(2010) , 10.1097/YCO.0B013E3283387B50
Joël R. Drevet, The antioxidant glutathione peroxidase family and spermatozoa: A complex story Molecular and Cellular Endocrinology. ,vol. 250, pp. 70- 79 ,(2006) , 10.1016/J.MCE.2005.12.027
Joachim Bleys, Ana Navas-Acien, Eliseo Guallar, Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. JAMA Internal Medicine. ,vol. 168, pp. 404- 410 ,(2008) , 10.1001/ARCHINTERNMED.2007.74
Alison Sutherland, Dong-Hyun Kim, Caroline Relton, Yoon-Ok Ahn, John Hesketh, None, Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer. Genes and Nutrition. ,vol. 5, pp. 215- 223 ,(2010) , 10.1007/S12263-010-0176-8
M Persson-Moschos, G Alfthan, B Åkesson, Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium. European Journal of Clinical Nutrition. ,vol. 52, pp. 363- 367 ,(1998) , 10.1038/SJ.EJCN.1600565