作者: Joyce C. McCann , Bruce N. Ames
DOI: 10.1096/FJ.11-180885
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摘要: The triage theory proposes that modest deficiency of any vitamin or mineral (V/M) could increase age-related diseases. V/M-dependent proteins required for short-term survival and/or reproduction (i.e., "essential") are predicted to be protected on V/M over other "nonessential" needed only long-term health. result is accumulation insidious damage, increasing disease risk. We successfully tested the against published evidence K. Here, we review about half 25 known mammalian selenoproteins; all those with mouse knockout human mutant phenotypes used as criteria a classification essential nonessential. Five selenoproteins (Gpx4, Txnrd1, Txnrd2, Dio3, and Sepp1) were classified 7 (Gpx1, Gpx 2, 3, Dio1, Dio2, Msrb1, SelN) On selenium (Se) deficiency, nonessential selenoprotein activities concentrations preferentially lost, one exception (Dio1 in thyroid, which predict conditionally essential). Mechanisms include requirement special form tRNA sensitive Se translation mRNAs except Dio1. same set diseases conditions, including cancer, heart disease, immune dysfunction, prospectively associated also genetic dysfunction selenoproteins, suggesting causal factor, possibility strengthened by mechanistic evidence. Modest common many parts world; optimal intake prevent future disease.