Trypanosoma cruzi Cell Invasion Mechanisms

摘要: Mammalian cell invasion by Trypanosoma cruzi is a multi-step process that requires the interaction of various parasite and host molecules activation signal transduction pathways in both cells. Depending on strain, developmental stage type target cell, distinct sets may be engaged. The metacyclic trypomastigote, which initiates infection mammalian host, expresses stage-specific surface glycoprotein gp82 mucin-like molecule gp35/50. binding these proteins to during triggers Ca2+ responses Cell-derived trypomastigotes trigger signaling from receptors for agonists, such as bradykinin TGFα, trypomastigote Ca2+-agonist, generated precursor oligopeptidase B. Trypomastigote molecules, trans-sialidase, mucin SSp-3 Tc85, contains sites laminin cytokeratin 18, also involved invasion. In cells, released internal compartments IP3-dependent manner required translocation lysosomes site entry, contributes formation vacuole membrane surrounding penetration.