Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.
作者： Jian Song , Mengyao Zhao , Xin Liu , Yuchen Zhu , Xiaosong Hu
DOI: 10.1016/J.FCT.2013.05.003
关键词:
摘要: Acrylamide (AA) occurs in many cooked starchy foods and has caused widespread concern as a possible carcinogen. In the present study, we investigate intervention of AA toxicity MDA-MB-231 cells pretreated with cyanidin-3-glucoside (Cy-3-glu). Compared to treated AA, Cy-3-glu significantly inhibited AA-induced cytotoxicity, reduced reactive oxygen species (ROS) generation, recovered glutathione (GSH) depletion decreased activities peroxidase (GPx) S-transferase (GST). Moreover, expression GPx1, GSTP1 gamma-glutamyl cysteine synthase (γ-GCS) were enhanced, cytochrome P450 2E1 (CYP2E1) was by pretreatment Cy-3-glu. presents protective role against oxidative stress induced cells.
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