Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo.
作者： Lulu Zhang , Huanjie Zhang , Yutian Miao , Sijia Wu , Haiqing Ye
DOI: 10.1016/J.FCT.2012.05.060
关键词: Superoxide dismutase 、 Allicin 、 Glutathione 、 Acrylamide 、 Toxicity 、 Carcinogen 、 Biochemistry 、 Chemistry 、 In vivo 、 Hepatocyte
摘要: Acrylamide (AA) is known to be a neurotoxic, genotoxic, and carcinogenic compound. The presence of AA in foods causes public health concerns. In our previous study, we found that allicin can effectively reduce content Maillard model system. However, there has been no report on whether AA-induced toxicity vitro vivo. present evaluated the protective effect against hepatocyte damage cultured mouse primary hepatocytes liver. Our date suggested significantly decreased levels maleic dialdehyde (MDA) 8-hydroxy-desoxyguanosine (8-OHdG) both vivo study. Allicin also markedly increased activity total superoxide dismutase (SOD) level glutathione (GSH). study revealed 15 μM was optimum concentration for inhibiting damage. 20mg/kg b.w./day dose effects may due its ability scavenge free radicals effective recovery antioxidative defense system, block epoxidation process GA by P450 enzyme.
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