S-allyl cysteine prevents CCl(4)-induced acute liver injury in rats.
作者： Shintaro Kodai , Shigekazu Takemura , Yukiko Minamiyama , Seikan Hai , Satoshi Yamamoto
DOI: 10.1080/10715760601118361
关键词: Carbon tetrachloride 、 Liver injury 、 Malondialdehyde 、 Oxidative stress 、 Endocrinology 、 S-Allyl cysteine 、 Chronic liver disease 、 Biochemistry 、 Reactive oxygen species 、 Lipid peroxidation 、 Internal medicine 、 Chemistry
摘要: Aged garlic extract (AGE) possesses multiple biological activities. We evaluated the protective effect of S-allyl cysteine (SAC), one organosulfur compounds AGE, against carbon tetrachloride (CCl(4))-induced acute liver injury in rats. SAC was administrated intraperitoneally (50-200 mg/kg). significantly suppressed increases plasma ALT and LDH levels. also attenuated histological damage. CCl(4) administration induced lipid peroxidation accompanied by malondialdehyde hepatic 4-hydroxy-2-nonenal levels, dose-dependently these increases. The total level hydroxyoctadecadienoic acid (HODE), a new oxidative stress biomarker, closely correlated with amount These results suggest that decreased CCl(4)-induced attenuation stress, may be better therapeutic tool for chronic disease.
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