Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice.
作者： Yu-Wen Hsu , Chia-Fang Tsai , Wen-Kang Chen , Fung-Jou Lu
DOI: 10.1016/J.FCT.2009.06.015
关键词:
摘要: The present study examined the protective effects of seabuckthorn (Hippophae rhamnoides L., SBT) seed oil on carbon tetrachloride (CCl(4))-induced hepatic damage in male ICR mice. Our results showed that oral administration SBT at doses 0.26, 1.30, and 2.60 mg/kg for 8 weeks significantly reduced elevated levels alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP), triglyceride (TG), cholesterol least 13% serum, level malondialdehyde (MDA) liver 22%, was induced by CCl(4) (1 mL/kg) Moreover, treatment also found to increase activities superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), reductase (GSH-Rd), GSH content up 134%. optimal dose 0.26 mg/kg, as minimum amount exhibiting greatest hepatoprotective CCl(4)-induced injury. Overall, effect all tested be comparable silymarin (200 mg/kg) have been supported evaluation histopathology
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