Effects of S-Propargyl-Cysteine (SPRC) in Caerulein-Induced Acute Pancreatitis in Mice

摘要: Hydrogen sulfide (H(2)S), a novel gaseous messenger, is synthesized endogenously from L-cysteine by two pyridoxal-5'-phosphate-dependent enzymes, cystathionine β-synthase (CBS) and γ-lyase (CSE). S-propargyl-cysteine (SPRC) slow H(2)S releasing drug that provides cysteine, substrate of CSE. The present study was aimed to investigate the effects SPRC in an vivo model acute pancreatitis (AP) mice. AP induced mice hourly caerulein injections (50 µg/kg) for 10 hours. Mice were treated with (10 mg/kg) or vehicle (distilled water). administered either 12 h before 3 induction pancreatitis. sacrificed 1 after last injection. Blood, pancreas lung tissues collected processed measure plasma amylase, H(2)S, myeloperoxidase (MPO) activities cytokine levels lung. results revealed significant reduction inflammation, both associated given prior AP. Furthermore, beneficial pancreatic pulmonary pro-inflammatory cytokines increase anti-inflammatory cytokine. did not cause improvement inflammation. Plasma concentration showed difference between control, (administered AP) treatment groups. In conclusion, these data provide evidence protective possibly virtue its release endogenous H(2)S.