Reactivity of Germ Cell Maturation Stage-specific Markers in Classical and Spermatocytic Seminoma

作者: L. H. J. Looijenga , H. Stoop , R. J. H. L. M. van Gurp , R. de Krijger , J. W. Oosterhuis

DOI: 10.1007/978-1-4471-3281-3_6

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摘要: This paper presents data supporting the model that classical seminoma originates from a primordial germ cell/gonocyte in which maturation is blocked. Although spermatocytic might also originate an embryonic cell, it retains capacity to undergo further maturation, including partial meiosis. Moreover, we identified immunohistochemical markers helpful diagnosis of seminomas.

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