Transaminase profile and hepatic histopathological traits in Piaractus mesopotamicus exposed to insecticide Diflubenzuron.

摘要: Diflubenzuron (DFB) is a widely used insecticide to control ectoparasites in fish farming. Although therapeutic concentrations (i.e., 50 100 mg/L) are safe as they fail induce mortality, can promote tissue changes. In Brazil, Pacu (Piaractus mesopotamicus) native species for commercial production, and it remains crucial determine underlying mechanisms mitigate the potential effects of pathogens on productivity. The aim this study was analyze transaminase profile histopathological changes liver P. mesopotamicus exposed DFB bath. Hence, were an immersion bath containing 70 mg/L nominal concentration Difluchem 240 SC® (24% (m/m) DFB) 30 (n = 10), 60 120 min every 24 h 3 days. Following exposure, plasma transaminases histology analyzed. DFB-exposed fish, levels aspartate (AST) alanine (ALT) elevated when compared with at min. Furthermore, morphology altered based exposure times. Compared controls, degree reversible damage (degree change (DTC)) demonstrated high scores all times, no difference between individual groups. Irreversible increased 120-min baths. These findings highlight impact mg/L), revealing that 60-min bathing induces irreversible progressive hepatic