SUCCESS IN THE TREATMENT OF HYPERTENSION : A STATUS REPORT

摘要: BACKGROUND: Pharmacological intervention studies aimed at lowering elevated blood pressure have shown that stroke, and to a lesser degree coronary heart disease, morbidity mortality are positively affected. These beneficial effects appear been obtained mainly with diuretics beta-adrenoceptor blocking agents, as in meta-analysis of 13 large prospective trials hypertension. PREVIOUS STUDIES: Benefits pharmacological antihypertensive treatment were observed the patients malignant hypertension late 1950s early 1960s. Many these conducted before became clinically available long first reports effect beta-blockers published. PROSPECTIVE Prospective newer agents such calcium antagonists angiotensin converting enzyme inhibitors currently progress. Three recently, open, retrospective case-control dealing comparisons various drug classes regard their on cardiovascular attracted interest. FUTURE BENEFITS: Another question considerable clinical importance is how far should be lowered order extract maximum benefit treatment. This issue being investigated.