Abdominal fat and birth size in healthy prepubertal children.

摘要: BACKGROUND: Studies examining the foetal origins hypothesis suggest that small birth size may be a marker of adaptations programme future propensity to adult disease. We explore relate fat distribution in childhood and link between OBJECTIVE: To investigate relationship abdominal fat, blood pressure, lipids, insulin insulin:glucose ratio prepubertal children. DESIGN: Cross-sectional study, based on cohort consecutive full-term births. SUBJECTS: Two hundred fifty-five (137 females) healthy, 7- 8-y-old MEASUREMENTS: Body composition was measured by dual energy X-ray absorptiometry. Lipid, glucose profiles were after an overnight fast automated BP monitor used for pressure measurements. RESULTS: There negative association weight s.d. score across range normal weights (β=−0.18; 95% CI=−0.31 −0.04, P=0.009) positive with at 7/8 y (β=0.35; CI=0.24 0.46, P<0.001). Children who born lowest had greatest significantly more (P<0.001) as percentage total (6.53±1.3%) than those highest (4.14±0.5%). Similar results seen if head circumference, but not ponderal index, indicator size. Increased associated higher cholesterol:HDL cholesterol, triglyceride concentration increased diastolic pressure. CONCLUSIONS: Birth independently predicted fat. amount tended lighter gained centiles. precursor risk factors ischaemic heart