The incidence and risk factors of de novo skin cancer in the liver transplant recipients.

摘要: Background: Liver transplantation (LT) increases the risk of de novo malignancies including skin cancers. However, factors for this type cancers have not been well studied. Objective: To determine incidence cancer in LT recipients, and to identify cancer. Methods: We identified all adult patients who underwent developed post-LT at our institution between 1996 2009. excluded with history prior LT. also studied a control group during same period but did develop cancer; was matched (1:2) age, gender geographical place residence. Results: Over median (IQR) follow-up 41.5 (18.0, 98.6) months, 23 (2.3%) 998 post-LT, whom 10 were squamous cell carcinoma, 9 basal carcinoma 4 melanoma. After adjusting confounding variables, subjects had combined liver/kidney transplant 22 (95% CI: 5.1–99) times higher hazard compared alone. Furthermore, non-skin 8.6–60) developing after transplant. Patients alcohol consumption, as underlying etiology liver disease, 1.2–12.9) transplantation. Type or duration immunosuppression associated increased post-LT. The survival outcome affected by development post-LT. Conclusion: Skin is relatively common recipients should be monitored, particularly pretransplant malignancy, kidney having alcoholic cirrhosis cause disease.