Synthesis of oxazoles by silver catalysed oxidative decarboxylation–cyclization of α-oxocarboxylates and isocyanides

摘要: A silver catalysed synthesis of oxazoles by the oxidative decarboxylation–cyclization α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct oxazole rings compared traditional methods. Mechanistic investigations such as operando IR, EPR radical inhibition experiments were carefully done confirmed acyl cation Ag(II) intermediates in this transformation, involvement decarboxylative process.