Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies.
作者： Aaron Simpson , Wilfride Petnga , Valentine M. Macaulay , Ulrike Weyer-Czernilofsky , Thomas Bogenrieder
DOI: 10.1007/S11523-017-0514-5
关键词:
摘要: … agents with standard cytotoxic agents, other targeted agents, endocrine therapies, or … -targeted combinations. Herein, we review the preclinical and clinical experience with IGF-targeted …
springer.com
paperity.org参考文章(222)
J-Y Kato, H Matsushime, SW Hiebert, ME Ewen, CJ Sherr, Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes & Development. ,vol. 7, pp. 331- 342 ,(1993) , 10.1101/GAD.7.3.331
James P. Barrett, Aedín M. Minogue, Aidan Falvey, Marina A. Lynch, Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages Experimental Cell Research. ,vol. 335, pp. 258- 268 ,(2015) , 10.1016/J.YEXCR.2015.05.015
William J. Gradishar, Denise A. Yardley, Rachel Layman, Joseph A. Sparano, Ellen Chuang, Donald W. Northfelt, Gary N. Schwartz, Hagop Youssoufian, Shande Tang, Ruslan Novosiadly, Amelie Forest, Tuan S. Nguyen, Jan Cosaert, Dmitri Grebennik, Paul Haluska, Clinical and Translational Results of a Phase II, Randomized Trial of an Anti–IGF-1R (Cixutumumab) in Women with Breast Cancer That Progressed on Endocrine Therapy Clinical Cancer Research. ,vol. 22, pp. 301- 309 ,(2016) , 10.1158/1078-0432.CCR-15-0588
Laura W. Bowers, Emily L. Rossi, Ciara H. O’Flanagan, Linda A. deGraffenried, Stephen D. Hursting, The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link Frontiers in Endocrinology. ,vol. 6, pp. 77- 77 ,(2015) , 10.3389/FENDO.2015.00077
Katsuaki Sato, Toshiki Takemoto, Takuya Iwasaki, Tetsuya Mitsudomi, Kenichi Suda, Hiroshi Mizuuchi, The insulin-like growth factor 1 receptor causes acquired resistance to erlotinib in lung cancer cells with the wild-type epidermal growth factor receptor International Journal of Cancer. ,vol. 135, pp. 1002- 1006 ,(2014) , 10.1002/IJC.28737
Xiaolin Wan, Choh Yeung, Christine Heske, Arnulfo Mendoza, Lee J. Helman, IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma Neoplasia. ,vol. 17, pp. 358- 366 ,(2015) , 10.1016/J.NEO.2015.03.001
Weiya Xia, Bill Spohn, Mong-Hong Lee, Mien-Chie Hung, Binhua P. Zhou, Yong Liao, Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biology. ,vol. 3, pp. 245- 252 ,(2001) , 10.1038/35060032
Yongik Lee, Yian Wang, Michael James, Joseph H. Jeong, Ming You, Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells Molecular Carcinogenesis. ,vol. 55, pp. 991- 1001 ,(2016) , 10.1002/MC.22342
Hongxin Cao, Wei Dong, Hongchang Shen, Jun Xu, Linhai Zhu, Qi Liu, Jiajun Du, Combinational Therapy Enhances the Effects of Anti-IGF-1R mAb Figitumumab to Target Small Cell Lung Cancer PLOS ONE. ,vol. 10, pp. e0135844- ,(2015) , 10.1371/JOURNAL.PONE.0135844
C Maris, N D'Haene, A-L Trépant, M Le Mercier, S Sauvage, J Allard, S Rorive, P Demetter, C Decaestecker, I Salmon, IGF-IR: a new prognostic biomarker for human glioblastoma British Journal of Cancer. ,vol. 113, pp. 729- 737 ,(2015) , 10.1038/BJC.2015.242