Tests of efficacy of antidotes for removal of methylmercury in human poisoning during the Iraq outbreak

摘要: Three complexing agents and a thiolated resin were tested for their ability to reduce the T 1/2 of methylmercury in blood during an outbreak human poisoning. The slope line relating natural logarithm concentration time treatment was calculated by parametric (linear regression) nonparametric (two-point) method. mean each group from slope. Both linear regression two-point methods yield similar values. "two-point" will be quoted here. six patients receiving no specific 65 days 10 placebo 61 days, these values did not differ those reported literature. All four treatments significantly reduced below combined groups. Sodium 2,3-dimercaptopropane-1-sulfonate most effective agent, reducing days. given eight produced 20 penicillamines also significant reduction values; D-penicillamine 12 26 N-acetyl-DL-penicillamine 17 yielded 24 This is first report effects sodium subjects exposed methylmercury. No adverse observed any A clinical trial possible but it concluded that levels accelerate excretion are probably clinically useful if before irreversible damage has occurred.