Molecular hydrogen increases resilience to stress in mice.

摘要: The inability to successfully adapt stress produces pathological changes that can lead depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities neuroprotective effects. However, the potential role of molecular in stress-related disorders is still poorly understood. present study aims investigate effects gas on resilience mice. results showed repeated inhalation hydrogen-oxygen mixed [67%:33% (V/V)] significantly decreased both acute chronic stress-induced depressive- anxiety-like behaviors mice, assessed by tail suspension test (TST), forced swimming (FST), novelty suppressed feeding (NSF) test, open field (OFT). ELISA analyses blocked CMS-induced increase serum levels corticosterone, adrenocorticotropic hormone, interleukin-6, tumor necrosis factor-α mice exposed mild stress. Finally, adolescence increased early adulthood, which illustrates long-lasting This was likely mediated inhibiting hypothalamic-pituitary-adrenal axis inflammatory responses These warrant further exploration for developing as a novel strategy prevent occurrence disorders.