Molecular basis of bacterial outer membrane permeability.

摘要: * Corresponding author. are very toxic to gram-positive bacteria (57, 230, 242). In enteric gram-negative bacteria, which live in the intestinal tract of animals, the outer membrane has developed into a very effective barrier, giving protection to cells from the detergent action of bile salts and degradation by digestive enzymes (207). At the same time the outer membrane of enteric and some other gram-negative bacteria acts as a strong permeability barrier to many antibiotics that are effective against other bacteria (eg, macrolides, novobio …