"Nonalcoholic steatohepatitis" induced by massive doses of synthetic estrogen.

摘要: We have noticed that functional disorders of the liver characterized by hepatomegaly and an increase in serum gamma-glutamyl transpeptidase develop patients with prostatic cancer who are placed under longterm therapy massive doses estrogen after castration. performed laparoscopy six cases so we could study morphology liver. Our findings were as follows. In five, histological features biopsies very similar to those seen alcoholic hepatitis. spite this fact, two five had no history alcohol consumption. Furthermore, one other case, damage resembling hepatitis developed during abstinence. The these three suggested long-term, synthetic may lead injury nonalcoholics. ultrastructural cells also suggestive adverse effect treatment. All negative for B surface antigen. Recent reports demonstrated some nonalcoholics indicative This particular condition was termed “nonalcoholic steatohepatitis” Ludwig et al. It is quite likely responsible when it used doses.