Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death

作者: Gordon B. Mills , Douglas R. Green , Eckard Weber

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摘要: The use of caspase inhibitors for treating, ameliorating, and preventing non-cancer cell death during chemotherapy radiation therapy treating ameliorating the side effects cancer is disclosed.

参考文章(86)
J. Lotem, L. Sachs, Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 12507- 12512 ,(1996) , 10.1073/PNAS.93.22.12507
Shuji Kubo, Maosen Sun, Michio Miyahara, Kazuhiro Umeyama, Ken-ichi Urakami, Tetsuro Yamamoto, Cornelis Jakobs, Ichiro Matsuda, Fumio Endo, Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 9552- 9557 ,(1998) , 10.1073/PNAS.95.16.9552
Todd L. Graybill, Catherine P. Prouty, Gary J. Speier, Denton Hoyer, Roland E. Dolle, Carla T. Helaszek, Mark A. Ator, Joanne Uhl, Joost Strastes, α-((Tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1β converting enzyme (ICE) Bioorganic & Medicinal Chemistry Letters. ,vol. 7, pp. 41- 46 ,(1997) , 10.1016/S0960-894X(96)00574-4
Laszlo Revesz, Chantal Briswalter, Richard Heng, Albert Leutwiler, Rudolf Mueller, Hans-Juerg Wuethrich, Synthesis of P1 aspartate-based peptide acyloxymethyl and fluoromethyl ketones as inhibitors of interleukin-1β-converting enzyme Tetrahedron Letters. ,vol. 35, pp. 9693- 9696 ,(1994) , 10.1016/0040-4039(94)88361-0
H. Hara, R. M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan, M. A. Moskowitz, Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 2007- 2012 ,(1997) , 10.1073/PNAS.94.5.2007
S Peleg, H Qiu, S Reddy, D Harris, Q Van, E H Estey, M Talpaz, Z Estrov, 1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production. Journal of Clinical Investigation. ,vol. 100, pp. 1716- 1724 ,(1997) , 10.1172/JCI119696
Emad S Alnemri, David J Livingston, Donald W Nicholson, Guy Salvesen, Nancy A Thornberry, Winnie W Wong, Junying Yuan, Human ICE/CED-3 Protease Nomenclature Cell. ,vol. 87, pp. 171- 171 ,(1996) , 10.1016/S0092-8674(00)81334-3
P G Conaldi, L Biancone, A Bottelli, A Wade-Evans, L C Racusen, M Boccellino, V Orlandi, C Serra, G Camussi, A Toniolo, HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation. Journal of Clinical Investigation. ,vol. 102, pp. 2041- 2049 ,(1998) , 10.1172/JCI3480
STEN ORRENIUS, Apoptosis : molecular mechanisms and implications for human disease Journal of Internal Medicine. ,vol. 237, pp. 529- 536 ,(1995) , 10.1111/J.1365-2796.1995.TB00881.X
Jean T. Greenberg, Allan Guo, Daniel F. Klessig, Frederick M. Ausubel, Programmed cell death in plants : a pathogen-triggered response activated coordinately with multiple defense functions Cell. ,vol. 77, pp. 551- 563 ,(1994) , 10.1016/0092-8674(94)90217-8