Role of Pore-Forming Toxins in Bacterial Infectious Diseases

摘要: SUMMARY Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and required for virulence in a large number of important pathogens, including Streptococcus pneumoniae, group A B streptococci, Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis. PFTs generally disrupt host cell membranes, but they can have additional effects independent pore formation. Substantial effort has been devoted to understanding molecular mechanisms underlying functions certain model PFTs. Likewise, specific pathways mediating survival immune responses face toxin-mediated cellular damage delineated. However, less is known about overall during infection vivo . This review focuses on themes area PFT biology, with an emphasis studies addressing roles ex models colonization or infection. Common include disruption epithelial barrier function evasion responses, which contribute growth spreading. The widespread nature make this attractive target development new virulence-targeted therapies that may broad activity against human pathogens.