Polymer-drug conjugates with tether groups for controlled drug delivery
作者： Thomas Schluep , Jungyeon Hwang , Mark E Davis , Tianyi Ke , Jing-Jou Lim
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摘要: The present invention relates to novel compositions comprising polymeric moieties covalently attached therapeutic agents, wherein the agent is moiety through a tether. By selecting from variety of tether groups and targeting ligands polymers methods for controlled delivery agents. also treating subjects with described herein. comprises self-cyclizing moiety, such as -S-CH2-CH2- CO-, -NR-CH2-CH2-NR-CO- -S-CH2-CH2-NR-CO-. drug conjugates cyclodextrin-based polymers.
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