Auristatin compounds and conjugates thereof
作者： Timothy B. Lowinger , Aleksandr V. Yurkovetskiy , Mao Yin , Cheri A. Stevenson , Patrick R. Conlon
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摘要: Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) polymeric carrier substituted with one or more -L D -D, the being connected to by L P . Each occurrence of is independently an compound. linkers connecting therapeutic agent PBRM respectively. Also disclosed scaffolds useful for conjugating form polymer-drug-PBRM described herein, compositions comprising conjugates, methods their preparation, treating various disorders compositions.
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