Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.

摘要: // Junjie Zhao 1, 2, * , Weidong Xu Minghui He 3 Zhensheng Zhang 2 Shuxiong Zeng Chong Ma Yinghao Sun Chuanliang 1 Department of Urology, Yantai Yuhuangding Hospital, 264000, China Changhai The Second Military Medical University, Shanghai 200433, Cancer Research Department, BGI-Shenzhen, Yantian District, Shenzhen, Guangdong 518083, These authors have contributed equally to this work Correspondence to: Xu, email: xuchuanliang@vip.126.com Keywords: bladder cancer, tumor progression, IPO11, prognosis, whole-exome sequencing Received: July 10, 2016     Accepted: September 06, Published: ABSTRACT Non-muscle-invasive cancer (NMIBC) often has a worse prognosis following its progression muscle-invasive (MIBC), despite radical cystectomy with pelvic lymph node dissection combined chemotherapy. Therefore, the discovery novel biomarkers for predicting disease and therapeutic targets preventing it is crucial. We performed analyze superficial tissues (T sup ) basal bas from MIBC patients identified previously unreported copy number variations in IPO11 that warrants further investigation as molecular target. In addition, we significant association between absolute mRNA expression found high importin-11 was correlated poor 3-year overall survival (OS), cancer-specific (CSS) cancer-free (CFS) compared low BCa patients. Importin-11 overexpression also an independent risk factor CSS CFS Our study revealed amplification contributes these changes are unfavorable prognostic factors NMIBC. Thus, promising