PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors.

摘要: Bladder cancer (BC) is the fifth most common in world, being non-muscle invasive tumors (NMIBC) frequent. NMIBC shows a very high frequency of recurrence and, certain cases, tumor progression. The phosphatidylinositol 3-kinase (PI3K) pathway, which controls cell growth, tumorigenesis, invasion and drug response, frequently activated numerous human cancers, including BC, part through alterations PIK3CA gene. However, significance gene with respect to clinicopathological characteristics, particular progression, remains elusive. Here, we analyzed presence mutations FGFR3 genes copy number bladder their correspondent paired normal samples from 87 patients. We observed an extremely (mutations, gains, or both) samples, affecting primarily T1 T2 tumors. A significant tissues also showed coincident those found corresponding sample. In low-grade associated mutations. Alterations resulted increased Akt activity Interestingly, alterations, mutations, significantly reduced Importantly, may influence clinical outcome patients bearing gene, was mutated, wt These findings have relevance terms using PI3K-targeted therapies for BC treatment.