The oncogenic role of the cochaperone Sgt1
作者： H Ogi , Y Sakuraba , R Kitagawa , L Xiao , C Shen
关键词:
摘要: Sgt1/Sugt1, a cochaperone of Hsp90, is involved in several cellular activities including Cullin E3 ubiqutin ligase activity. The high level Sgt1 expression colorectal and gastric tumors suggests that tumorigenesis. Here, we report overexpressed colon, breast lung tumor tissues Ewing sarcoma rhabdomyosarcoma xenografts. We also found heterozygous knockout resulted suppressed Hras-mediated transformation vitro formation p53−/− mouse embryonic fibroblast cells significantly increased survival mice. Moreover, depletion inhibited the growth destabilized EWS-FLI1 PAX3-FOXO1 oncogenic fusion proteins, respectively, which are required for growth. Our results suggest contributes to cancer development by stabilizing oncoproteins potential therapeutic target.
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