CGRP may play a causative role in migraine

作者: LH Lassen , PA Haderslev , VB Jacobsen , HK Iversen , B Sperling

DOI: 10.1046/J.1468-2982.2002.00310.X

关键词:

摘要: Calcitonin gene-related peptide (CGRP) has been detected in increased amounts external jugular venous blood during migraine attacks. However, it is unknown whether this secondary to or CGRP may cause headache. In a double-blind crossover study, the effect of human alphaCGRP (2 microg/min) placebo infused intravenously for 20 min was studied 12 patients suffering from without aura. Headache intensity scored on scale 0 10. Two were excluded due severe hypotension and one because she had an infection. first hour median peak headache score 1.0 halphaCGRP group vs. (P < 0.01). During following 11 h all experienced headaches after patient = 0.0004). The maximal 4 0.006). three halphaCGRP, but no placebo, delayed fulfilled IHS criteria As intravenous administration causes migraineurs, our study suggests that increase observed spontaneous attacks play causative role.

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