Regulation of IgA secretion by T cell clones derived from the human gastrointestinal tract.

摘要: The role of T cells in Ig isotype regulation is still unclear. To address this question, we generated mitogen-stimulated cell clones from normal human lymphoid follicles the gut-associated tissue (appendix). Both and clonal supernatants provided preferential help for IgA secretion by PWM-stimulated B cells. Many these CD3+, CD4+, 4B4+, DR+ helper co-expressed Fc-gamma Fc-alpha R, but there was poor correlation between expression R (p = 0.31). Most helped both IgM+A- IgM-A+ populations to secrete IgA, suggesting that they mediate switch isotype-uncommitted as well post-switch expansion IgA-committed cells; however, some much more than populations, that, case, regulatory effect predominantly at level switch. In all, results show mucosal immune system contains individual which are capable positively regulating IgA-specific differentiation two levels development, thus allowing efficient generation IgA-secreting