Role of IL-6 in human antigen-specific and polyclonal IgA responses.

摘要: It is now well established that several cytokines are involved in B cell activation, proliferation, and differentiation. From earlier studies, it became clear some of these acted later responses contributed to terminal differentiation immunoglobulin synthesise1. A prominent cytokine among was a factor originally termed cell-differentiation factor, which could be distinguished from cell-stimulating factor-1 (BSF-1), or IL-4, subsequently BSF-22,3. When BSF-2 purified cloned3–5, shown identical other cloned proteins, e.g., interferon beta (IFN-β)6, the 26kDa protein7, hybridoma growth factor8–10, renamed IL-6.