Electrophysiological studies of cervical vagus nerve stimulation in humans: I. EEG effects.

作者: Edward J. Hammond , Basim M. Uthman , Steven A. Reid , B. J. Wilder

DOI: 10.1111/J.1528-1157.1992.TB01752.X

关键词:

摘要: Summary: Evidence from studies of experimental animals indicates that electrical stimulation the vagus nerve alters EEGs under certain stimulus parameters. We report EEG effects in 9 patients with medically intractable seizures as part a clinical trial chronic vagal for control epilepsy. The mechanism action antiepileptic effect is unknown, and we believed analysis electrophysiologic would help elucidate brain areas affected. left neck was stimulated programmable implanted stimulator. Stimulation at various frequencies amplitudes had no noticeable on activity whether patient general anesthesia, awake, or asleep, but may interrupt ongoing ictal activity.

参考文章(21)
O. Pompeiano, J. Magnes, G. Moruzzi, Synchronization of the EEG produced by low-frequncy electrical stimulation of the region of the solitary tract Archives Italiennes De Biologie. ,vol. 99, pp. 33- 67 ,(1961) , 10.4449/AIB.V99I1.3445
J.J. Puizillout, F. Gambarelli, Electrophysiological and morphological properties of type C vagal neurons in the nodose ganglion of the cat. Journal of The Autonomic Nervous System. ,vol. 29, pp. 49- 58 ,(1989) , 10.1016/0165-1838(89)90019-2
Emmanuel Balzamo, Ghislaine Gayan-Ramirez, Yves Jammes, Pulmonary vagal sensory afferents and spontaneous EEG rhythms in the cat sensorimotor cortex. Journal of The Autonomic Nervous System. ,vol. 30, pp. 149- 157 ,(1990) , 10.1016/0165-1838(90)90139-A
B.J. WILDER, BASIM M. UTHMAN, EDWARD J. HAMMOND, Vagal stimulation for control of complex partial seizures in medically refractory epileptic patients. Pacing and Clinical Electrophysiology. ,vol. 14, pp. 108- 115 ,(1991) , 10.1111/J.1540-8159.1991.TB04054.X
Edward J. Hammond, Basim M. Uthman, Steven A. Reid, B. J. Wilder, R. Eugene Ramsay, Vagus nerve stimulation in humans: neurophysiological studies and electrophysiological monitoring. Epilepsia. ,vol. 31, ,(1990) , 10.1111/J.1528-1157.1990.TB05850.X
J. Zabara, Peripheral control of hypersynchronous discharge in epilepsy Electroencephalography and Clinical Neurophysiology. ,vol. 61, ,(1985) , 10.1016/0013-4694(85)90626-1
Edward J. Hammond, Basim M. Uthman, Steven A. Reid, B. J. Wilder, Electrophysiologic studies of cervical vagus nerve stimulation in humans: II. Evoked potentials. Epilepsia. ,vol. 33, pp. 1021- 1028 ,(1992) , 10.1111/J.1528-1157.1992.TB01753.X
Emmanuel Balzamo, Ghislaine Gayan-Ramirez, Yves Jammes, Quantitative EEG changes under various conditions of hyperventilation in the sensorimotor cortex of the anaesthetized cat. Electroencephalography and Clinical Neurophysiology. ,vol. 78, pp. 159- 165 ,(1991) , 10.1016/0013-4694(91)90116-L